Background
Since acute appendicitis in children can be treated differently, we investigated the combined diagnostic modelof interleukin-6, Procalcitonin and Ferritin for acute uncomplicated appendicitis, acute complicated appendicitis and a control group .
Materials and Methods: A retrospective study included patients who underwent appendectomy for acute appendicitis over a period of five years. In this prospective single-centered cohort study for IL-6, Procalcitonin and Ferritin in serum were assayed preoperatively. Children aged to 18 years old were divided into three groups: AcA, AuA, and Ctr.The predictive values of biomarkers were evaluated by receiver operating characteristics.
Results: A total of 152 participants were enrolled, including AcA (n = 54), AuA (n = 40) and Ctr (n = 58). The combined diagnostic model was established and showed that combined diagnostic model AA vs Ctr reached a sensitivity of 90.3 %, a specificity of 90.8 % and an area under the curve of 0.86 (p<0.001). The combined diagnostic model AcA vs AuA reached a sensitivity of 60 %, a specificity of 70 %. A receiver operating characteristic curve was constructed to define the best score performance
Conclusion: The combined diagnostic model of serums predictors at the emergency department may provide a new approach for differentiating between AcA , AuA, and other causes of abdominal pain.
Keywords: Appendicitis, children, biomarkers
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