Background: Appendiceal carcinoids are a rare, incidental finding during appendicectomies present in 0.2 – 0.35% of operations. They are considered to have low metastatic potential and as such are generally considered cured with simple appendicectomy. To date, there has been no formal investigation into the incidence among children in New Zealand.
Methods: A retrospective audit was conducted of all appendicectomies performed on children aged 0 – 16 at Christchurch Hospital from 2004 - 2014. Histology records were accessed and cases of appendiceal carcinoid were identified. Electronic records were used to evaluate long term outcomes. Chi square analyses were performed to compare local data with overseas reports.
Results: In total there were 13 cases from 1288 operations over the 11 year study period. Median age at presentation was 12.9 years (10 - 15) and there was no significant gender difference. The overall incidence was 1.01%; .four (30.1%) children were of Maori ethnicity with the remainder being New Zealand European. Median tumour size was 3.9mm, smaller than that reported in other centres (Table 1). All patients were alive without recurrence at the time of writing, median follow up 92 months.
Conclusion: There appears to be a higher incidence of appendiceal carcinoids among Canterbury children than reported elsewhere. It would be of interest to know whether this applies across the country and whether there is an ethnicity-related component.
Table:
|
Study centre |
n (cases) |
Incidence (%) |
p value Median |
Median size (mm) |
|
Perth [ |
21 |
0.35 |
<0.001 |
4.5 |
|
Kansas [2] |
9 |
0.2 |
<0.001 |
5-10 |
|
Texas [3] |
28 |
0.2 |
<0.001 |
7.0 |
|
Auckland [4 |
47 |
Not Reported |
- |
8.3 |
|
Christchurch |
13 |
1.01 |
- |
3.9 |
Keywords:
Background: Appendiceal carcinoids are a rare, incidental finding during appendicectomies present in 0.2 – 0.35% of operations. They are considered to have low metastatic potential and as such are generally considered cured with simple appendicectomy. To date, there has been no formal investigation into the incidence among children in New Zealand.
Methods: A retrospective audit was conducted of all appendicectomies performed on children aged 0 – 16 at Christchurch Hospital from 2004 - 2014. Histology records were accessed and cases of appendiceal carcinoid were identified. Electronic records were used to evaluate long term outcomes. Chi square analyses were performed to compare local data with overseas reports.
Results: In total there were 13 cases from 1288 operations over the 11 year study period. Median age at presentation was 12.9 years (10 - 15) and there was no significant gender difference. The overall incidence was 1.01%; .four (30.1%) children were of Maori ethnicity with the remainder being New Zealand European. Median tumour size was 3.9mm, smaller than that reported in other centres (Table 1). All patients were alive without recurrence at the time of writing, median follow up 92 months.
Conclusion: There appears to be a higher incidence of appendiceal carcinoids among Canterbury children than reported elsewhere. It would be of interest to know whether this applies across the country and whether there is an ethnicity-related component.
Table:
|
Study centre |
n (cases) |
Incidence (%) |
p value Median |
Median size (mm) |
|
Perth [ |
21 |
0.35 |
<0.001 |
4.5 |
|
Kansas [2] |
9 |
0.2 |
<0.001 |
5-10 |
|
Texas [3] |
28 |
0.2 |
<0.001 |
7.0 |
|
Auckland [4 |
47 |
Not Reported |
- |
8.3 |
|
Christchurch |
13 |
1.01 |
- |
3.9 |
Anahtar Kelimeler: